Symbol
Name
ID

Bach2
BTB and CNC homology, basic leucine zipper transcription factor 2
MGI:894679

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgA level

Decreased circulating IgE

Decreased circulating IgG level

Decreased circulating total IgM

Decreased basophil count

Decreased proportion of memory B cells

Splenomegaly

Colitis

Ulcerative colitis

Crohn's disease

Perinuclear antineutrophil antibody positivity

Recurrent sinopulmonary infections

Disease(s) Associated with BACH2

immunodeficiency 60

Mouse Phenotypes

immune system phenotype

abnormal B cell differentiation

abnormal class switch recombination

decreased transitional stage B cell number

increased immature B cell number

abnormal somatic hypermutation frequency

myeloid hyperplasia

increased eosinophil cell number

increased neutrophil cell number

increased granulocyte number

increased CD103-positive CD11b-low dendritic cell number

decreased CD11b-high dendritic cell number

increased CD11b-low dendritic cell number

absent germinal center B cells

decreased mature B cell number

decreased B-1a cell number

decreased B-2 B cell number

decreased follicular B cell number

decreased marginal zone B cell number

increased B-1 B cell number

decreased B cell number

increased KLRG1-positive NK cell number

decreased Ly6C-positive immature NK cell number

decreased Ly6C-positive mature NK cell number

decreased memory-marker NK cell number

increased memory-marker NK cell number

decreased NK cell number

increased NK cell number

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, alpha-beta memory T cell number

increased KLRG1+ CD4 alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

decreased effector memory CD8-positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta memory T cell number

decreased CD8-positive, naive alpha-beta T cell number

increased KLRG1+ CD8 alpha-beta T cell number

increased KLRG1-positive CD4-negative NK T cell number

decreased memory-marker CD4-negative NK T cell number

increased memory-marker CD4-negative NK T cell number

decreased CD4-negative NK T cell number

decreased NK T cell number

increased NK T cell number

increased effector memory T-helper cell number

increased KLRG1-positive gamma-delta T cell number

decreased regulatory T cell number

increased macrophage cell number

increased Ly6C high monocyte number

increased Ly6C low monocyte number

increased monocyte cell number

spleen hypoplasia

abnormal B cell physiology

decreased IgA level

decreased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG3 level

decreased IgG level

increased IgM level

Availability

Mouse Genotype

Bach2^M1Btlr/Bach2^M1Btlr

Bach2^m1Ccg/Bach2^m1Ccg

Bach2^m2Anu/Bach2^m2Anu

Bach2^{tm1a(EUCOMM)Wtsi}/Bach2^{tm1a(EUCOMM)Wtsi}

Bach2^{tm1b(EUCOMM)Wtsi}/Bach2^{tm1b(EUCOMM)Wtsi}

Bach2^tm1Igar/Bach2^tm1Igar

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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